Is it possible to have a backend without port 80?

In addition to the information sjr provided, that is specifically our Encryption Recommender Bot. It is only scanning on port 80 to figure out a recommendation for your site. Since you are on Full or Full(Strict) there should be no issue with.

The issues with 522 are more likely cause by something like rate limiting at your hosting provider, I would verify that our IPs are allowlisted there.