Initial server response time very slow in São Paulo

Even activating the cache everything rule, the TTFB for some regions, especially mine (São Paulo) is much higher than normal. I always got something around 45ms, but at this moment the value exceeds 1100ms, that is, more than 1 second for the first byte. I would like to know if anyone else is having this difficulty, because all my sites are freezing and taking a long time to load, especially images.
If I pause Cloudflare and use it directly on the server in the USA, the TTFB drops to approximately 200ms, that is, just activate it and the performance problems start at the same time. I even deleted a site and recreated it as a test, but there was no difference.

Thank you!