How often is this error happening?
Is there any user-visible problem, like not being able to reach out to the origin?
I’m asking this because this is a typical network-level error that is expected, e.g. when the Cloudflare machine to which cloudflared is connected is restarted, or if the routing path to it changes and anycast now sends you elsewhere.
That’s why cloudflared establishes 4 connections to 2 different anycast regions, such that it is extremely unlikely that ocasional errors like this one cause the origin to be fully unavailable.