Error 522 only with chromium and safari browsers (Firefox OK)

We just started getting this error 522 to our website only when using browsers that are not Firefox. This configuration with Cloudflare in front of our AWS based website has worked for years. Today out of nowhere now most browsers cannot access our site. I opened up a ticket, but haven’t heard a response. Just posting to see if anyone knows of known outages. I see on downdetector a huge spike for Cloudflare (and a bunch of sites actually) - I bet other sites that use Cloudflare.