Hi @rich.denning, here are some ideas for troubleshooting the 522, Community Tip - Fixing Error 522: Connection timed out. If you still see issues, login to Cloudflare and then contact Cloudflare Support.
Edit - The name servers associated with your email are different than the name servers associated with the domain. Aside from that, a 522 happens if the origin server does not respond to Cloudflare queries within 60 seconds. The connection gets timed out and the website responds Error 522, usually a blocking or rate limiting issue.