Historically Cloudflare has only supported HTTP/1.1 to your origin, but recently there has been some movement in Cloudflare supporting HTTP/2 to origin.
Enabling HTTP/2 on your origin may result in faster responses (especially with multiple requests) when handling any uncached assets, and it’s basically a one-line change for any modern nginx version.
Won’t hurt to enable http2 listen directive on Nginx origin as Cloudflare will use whichever protocol is supported on Nginx origin - right now that is HTTP/1.1 but if HTTP/2 connection to origin evolves, then you’d be ready.