Email routing failures

The response from the remote server was:

521 5.3.0 Upstream error, please check (link deleted) for possible reasons why. NsJ8GEyXLe2W

Nearly all emails to any of my forwarding addresses have suddenly started failing over the past 12 hours, with the above error being sent to the originator.

I haven’t changed anything so is this a system error with Cloudflare?