When i test 1.1.1.1/help i see Connectivity to Resolver IP Addresses IPv6, status is showing no.
is it because i dont have IPv6 setup? or this is normal?
if i configure my DNS to cloudflare will i face any issue in below case?
|1.1.1.1|Yes|
|1.0.0.1|Yes|
|2606:4700:4700::1111|No|
|2606:4700:4700::1001|No|
Yes, exactly. If you can’t send v6 requests you will not get a response. 
Thank you very much 