Once you are only using that name for web traffic, you should be ready to enable the 
Cloudflare proxy.
In Outlook I changed de smtp and imap server hostname in “mail.mysite.nl” (the MX record in Cloudflare will remain “mysite.nl”)
for now there is no connection, maybe I have to wait a bit before it works ?
If you mean the target of the MX record, it also needs to point to the FQDN of the mail hostname.
That determines how your inbound email is routed and is separate from your email client settings.
All of the filler IPs in your screenshot are the same. Are the real IPs also the same in your dashboard?
It now works as it should, thanks for the explanation and your patience !!!
ps. IPs in screenshot are fictitious
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