Haven’t tested yet, however may I ask if that does mean we’re going to have different WordPress instances accross different domain name(s), or within the same domain name, but different sub-directories, or maybe sub-domains and root (naked) domain, or some other combination?
I’d test it out first, therefore take a look and search if there isn’t already some topic about it by using the or at Cloudflare Docs for any possible feedback
Otherwise, post here and wait for a reply from somone who might have more insight and information to share.